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フルテキストURLA020023000304.pdf ( 1.0MB ) 公開日 2010-04-16
タイトルCerebral Effects of Nitrous Oxide
作成者Inoue, Seiichiro
作成者ヨミイノウエ, セイイチロウ
作成者所属山口大学医学部
内容記述(抄録等)The cerebral effects of 60 per cent (end-tidal concentration) nitrous oxide (N_2O) were examined in 29 dogs. With the inhalation of N_2O, the cerebral blood flow (CBF) increased, reaching a peak of 203 per cent of the control value at 7 minutes, and thereafter decreased gradually to 125 per cent of the control over a 60 minute-period. The mean cerebral metabolic rate for oxygen (CMR_O2) increased to about 120 per cent of the control value within 15 minutes and remained elevated during the inhalation of N_2O. There was no significant change in the mean arterial pressure (MAP), but a significant reduction in cerebral vascular resistance (CVR) was observed. The electroencephalogram (EEG) showed low voltage, slow wave activity with the inhalation of N20. After the intravenous injection of thiamyla1 (8 mg/kg), N_2O increased neither the CBF nor CMR_O2 for the first 30 minute-period, but produced predominant slow wave activity during the period. Pretreatment with reserpine (total 1.0 mg/kg) did not modify significantly the cerebral circulatory, metabolic and electrographic effects of N_2O. The cerebral responses to the alteration in Paco_2 did not differ significantly during increased metabolism with N_2O from the control without N_2O. In conclusion, N_2O is a cerebral metabolic stimulant which accompanies the increase in the CBF, and EEG slowing. The cerebral circulatory and metabolic stimulation was blocked by prior administration of thiamylal but not by pretreatment with reserpine.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
23
3-4
開始ページ197
終了ページ214
発行日1976-12
著者版/出版社版出版社版
リポジトリIDA020023000304
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020023000304