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フルテキストURLA020034000107.pdf ( 427.5KB ) 公開日 2010-04-19
タイトルInvolvement of Central Presynaptic Noradrenergic Neuron Activity in Head Twitches Induced by Bromocriptine in Rats
作成者Ushijima, Itsuko
Mizuki, Yasushi
Hara, Takahide
Kishimoto, Osamu
Soeda, Koichiro
Tsutsumi, Chigusa
Yamada, Michio
作成者ヨミウシジマ, イツコ
ミズキ, ヤスシ
ハラ, タカヒデ
キシモト, オサム
ソエダ, コウイチロウ
ツツミ, チグサ
ヤマダ, ミチオ
作成者所属山口大学医学部
内容記述(抄録等)The study was carried out in an attempt to understand the contribution of endogenous catecholamine on head twitches induced by bromocriptine (BRC), a dopamine D -2 recepter agonist, in rats. Intraperitoneal (I.p.) of BRC (1-10 mg/kg) induced head twitches which are prominent at 2.5mg/kg. The pretreatment with α-methyl-p-tyrosine (α-MPT ; 200 and 400 mg/kg) inhibited in dose-dependet manner, whereas reserpine (2mg/kg) did not affet but reserpine plus α-MPT (200mg/kg) markedly decreased. Apomorphine (0.1 and 1 mg/kg) tended to increase the behavior but no significant. Thyrotropin releasing hormone (TRH ; 5mg/kg) potentiated the behavior, whereas clonidine (0.05 and 1mg/kg) completely blocked, but phentolamine (10 mg/kg), a α-1 and α-2 receptor blocker, and yohimbine (1mg/kg), a direct α-2 recepter blocker, did not affect. Yonimbine, however, reversed inhibitory effect of low dose of clonidine (0.05 mg/kg). These results suggest that endogenous catecholamine especially noradrenarine synthesis and release mediated in presynaptic sites may be involved in head twitches induced by BRC.
本文言語eng
著者キーワードBromocriptine
Dopamine D-2 agonist
Head twitches
Noradrenaline synthesis and release
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
34
1
開始ページ47
終了ページ51
発行日1987-12
著者版/出版社版出版社版
リポジトリIDA020034000107
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020034000107