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フルテキストURLA020033000105.pdf ( 440.5KB ) 公開日 2010-04-19
タイトルDifferental Properties of Behavioral Responses to Bromocriptine and Apomorphine in Rats
作成者Ushijima, Itsuko
Mizuki, Yasushi
Soeda, Koichiro
Kishimoto, Osamu
Hara, Takahide
Habu, Kensuke
Watanbe, Katsumi
Yamada, Michio
作成者ヨミウシジマ, イツコ
ミズキ, ヤスシ
ソエダ, コウイチロウ
キシモト, オサム
ハラ, タカヒデ
ハブ, ケンスケ
ワタナベ, カツミ
ヤマダ, ミチオ
作成者所属山口大学医学部
内容記述(抄録等)The study was carried out in an attempt to understand the contribution of dopamine D-1 and D-2 receptor activities to yawing responses induced by bromocriptine (BRC) in rats. Intraperitoneal (I.p.)injection of BRC ranging from 1 to 20 mg/kg produced yawing behavior. The yawing behavior. The yawing response were increased by reserpine (2mg/kg) and α-methyl-p-tyrosine (α-MPT;200mg/kg) but decreased by α-MPT (400mg/kg).Reserpine (2mg/kg) plus α-MPT (200mg/kg) completely inhibited the yawing induced by BRC. The yawing response were stimulated by a low dose of apomorphine (0.1mg/kg). A dopamine receptor agonist, but were inhibited by a high dose (1mg/kg). Furthermore, BRC alone did not produce stereotypy but potentiated, in a dose-dependent manner, apomorphine (1mg/kg)^induced stereotypy, which was inhibited by sulpride (20mg/kg), a dopamine D-2 recepter antagonist. Theresult suggest that the important factors in the occurrence of yawing and stereotyped behaviors, include not only dopamine D-2 recepter stimulation, but also endogenous dopamine or D-1 recepter activation, and seem to depent upon the ratio and potency of D-1 recepter versus D-2 recepter activity.
本文言語eng
著者キーワードbromocriptine
dopamine D-2 agonist
yawning
stereotypy
endogenous dopamine
apomorphine
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
33
1
開始ページ33
終了ページ37
発行日1986-12
著者版/出版社版出版社版
リポジトリIDA020033000105
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020033000105