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フルテキストURLA020008000109.pdf ( 807.7KB ) 公開日 2010-04-16
タイトルEffects of X-Ray Irradiation on Tryptophan Pyrrolase Induction In Vivo and In Vitro
作成者Cha, Hi Sun
作成者所属山口大学医学部
内容記述(抄録等)Effects of whole body x-ray irradiation on the induction of tryptophan pyrrolase by tryptophan administration and also on the in vitro increment of tryptophan pyrrolase activity in rat liver homogenate incubated in tryptophan-containing complex medium were studied. 900 r of x-ray irradiation caused the increase in the substrate induced enzyme activity immediately as well as at 72 hours after exposure. The pattern of induction and decay course of tryptophan pyrrolase after tryptophan treatment, however, was not appreciably altered by x-ray irradiation. On the other hand, in vitro increments of tryptophan pyrrolase activity relative to original activity were significantly reduced in liver homogenate from x-ray irradiated rats, and this reduction in the in vitro inducibility by substrate addition in irradiated rat's liver homogenate was not prevented by prior treatment of irradiated animals with tryptophan. Possible roles of hormonal influences on the increased in vivo tryptophan pyrrolase induction after exposure and mitochondrial damage by x-ray irradiation relevent to the reduced in vitro inducibility are discussed. Acknowledgement-The author would like to thank Dr.keun-Bai Lee,professorof Biochemistry, and Dr. Min Wha Lee, Instructor of Biochemistry, Chonnam University Medical School, for advices and instructions. He is also indebted to De. Chi Yul Ahn, professor of X-ray, Catholic University Medical School and to Dr.DongJoon Kim, professor of Physiology, Ewha Woman's University Medical School, for their help performing of this investigation.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
8
1
開始ページ73
終了ページ82
発行日1961-03
著者版/出版社版出版社版
リポジトリIDA020008000109
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020008000109