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フルテキストURLA020026000106.pdf ( 1.4MB ) 公開日 2010-04-19
タイトルHyperplasia of Brunner's glands
作成者Sasaki, Kohsuke
Ogino, Tetsuro
Sasai, Kazuhiko
Suemori, Tagao
Emoto, Isao
Takahashi, Manabu
作成者ヨミササキ, コウスケ
オギノ, テツロウ
ササイ, カズヒコ
スエモリ, タガオ
エモト, イサオ
タカハシ, マナブ
作成者所属山口大学医学部
内容記述(抄録等)An unstable hemoglobin, Hb Iwata, F8 (α87) His → Arg, was discovered during a screening program for hemoglobin anomalies in the newborns. Studies of the family members of the proband revealed the father and the paternal grandmother to also carry the abnormal hemoglobin. None of the carriers of the abnormal hemoglobin manifested clinical symptoms, probably because Hb Iwata migrated between Hb A and A_2 in starch gen electrophoresis (pH 8.6), and was isolated by DE-52 column chromatography. Analysis of the amino acid composition of tryptic peptides from the α chain of Hb Iwata demonstrated the substitution of the proximal histidine by arginine. Results of the isopropanol, heat denaturation and Heinz body formation tests indicated instability of Hb Iwata. Hb Iwata rapidly auto-oxidized into semihemichrome and subsequently precipitated. The oxidation also accelerated heme loss, and the heme-depleted Hb Iwata tended to dessociate in reference to stereochemical properties other abnormal hemoglobins with substitution of the proximal or distal histidine.
本文言語eng
著者キーワードduodenal polyp
tumor of the duodenum
hamartoma of the dumodenum
duodenal adenoma
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
26
1-2
開始ページ43
終了ページ48
発行日1979-06
著者版/出版社版出版社版
リポジトリIDA020026000106
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020026000106