Japanese | English

トップページへ戻る

詳細

   
フルテキストURLA020026000104.pdf ( 842.6KB ) 公開日 2010-04-19
タイトルImmunotherapy as an Adjuvant Therapy for Malignant Melanoma of the Female Urethra : Report of a Case
作成者Yamamoto, Norio
Fukuda, Kazuo
Kiriyama, Tadao
Sakatoku, Jisaburo
作成者ヨミヤマモト, ノリオ
フクダ, カズオ
キリヤマ, タダオ
サカトク, ジサブロウ
作成者所属山口大学医学部
内容記述(抄録等)Mucosal immunity as well as enzymatic and mucociliary defense mechanism acts in the mucous membrane of nasal and paranasal sinus cavities, preventing viral, bacterial and other antigenic invasions. Chronic nasal and paranasal sinus infection is very common disease, but the etiology and pathogenesis of this entity is still a subject of controversy. To obtain an additional information about the pathogenesis of chronic paranasal sinusitis, we investigated secretory component (SC), lactoferrin and immunoglobulins in nasal secretions and nasal and paranasal sinus mucosae. Forty-seven specimens of nasal secretion were obtained by adsorption onto filter papers from patients with chronic rhinosinusitis, 74 specimens were from patients with allergic rhinitis and 40 from normal subjects. Tissue speciments of the inferior turbinate, nasal polyp, and maxillary and ethmoidal sinus mucosa were obtained from 32 patients who underwent paranasal sinus operation. These tissue specimens were subjected to the immunofluorescent observation and immunohistochemical SC affinity test of IgA immunocytes. Concentrations of IgA and IgG in both nasal secretions and sera were determined by single radial diffusion technique, while radioimmunoassay was employed to measure concentrations of SC and lactoferrin in nasal secretions. Mean concentrations of total protein, IgG and IgA in nasal secretions for patients with chronic rhinosinusitis exceeded significantly those of normal subjects. However, mean concentrations of SC and lactoferrin in nasal secretions from the group of chronic rhinosinusitis were less than those of normal subjects. Lactoferrin was chiefly synthesized in serous secretory cells of nasal and paranasal sinus mucosae. However, the production of this protein was reduced in chronic rhinosinusitis, even though glands were apparently abundant. Although IgA content in nasal secretions was elevated in chronic rhinosinusitis, the number of IgA immunocytes capable of binding SC was smaller than that of IgA immunocytes not binding SC. Findings of this investigation suggest that the function fo local mucosal immunity is limited in the nasal and paranasnasat sinus cavities of patients with chronic rhinosinusitis, and that antibodies originating from the plasma contribute significantly to the constitution of immunoglobulins in nasal secretions.
本文言語eng
著者キーワードimmunotherapy
melanoma
female urethra
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
26
1-2
開始ページ29
終了ページ34
発行日1979-06
著者版/出版社版出版社版
リポジトリIDA020026000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020026000104