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フルテキストURLA020035000104.pdf ( 521.6KB ) 公開日 2010-04-19
タイトルPharmacokinetic Study on One Case of High Dose Methotrexate Therapy with Leucovorin Rescue
作成者Fujita, Toshio
Kimoto, Hiroo
Koshiro, Akira
Yamamoto, Norio
Sakatoku, Jisaburo
作成者ヨミフジタ, トシオ
キモト, ヒロオ
コシロ, アキラ
ヤマモト, ノリオ
サカトク, ジサブロウ
作成者所属山口大学医学部
内容記述(抄録等)High-dose methotrexate therapy in a testicular was studied pharmacokinetically to obtain safe and effective massive methotrexate theraphy. The drug concentration in serum, cerebrospinal fluid and urinary excretion was analyzed according to two-or three-compartment open models. The ratio of exposure to methotrexate in the central vs. the peripheral compartments was calculated to be 1 : 0.14 by a two-compartment open model. A larger amount of methotrexate permeates into the peripheral compartment by passive transport when a high dose, as compared to the usual dose, is used. However, most of the administered mothotrexate is rapidly excreted in urine without any antitumor effects, The urinary excretion showed almost the same pharmacokinetical parameters as obtained from the serum data. The analysis based on a three-compartment open model indicates that the low and sustained serum concentration of methotrexate at the third phase was found to be governed by its release from the third compartment. General consideration about cancer chemotherapy using methotrexate are also discussed.
本文言語eng
著者キーワードMethotrexate
Pharmacokinetics
Cancer chemotherapy
High dose methotrexate therapy
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
35
1-2
開始ページ23
終了ページ29
発行日1989-06
著者版/出版社版出版社版
リポジトリIDA020035000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020035000104