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フルテキストURLA020036000302.pdf ( 2.0MB ) 公開日 2010-04-19
タイトルThe Role of H-Y Antigen in Acute Graft-Versus-Host Responses
作成者Nakatsuji, Tadako
Ishihara, Tokuhiro
作成者ヨミナカツジ, タダコ
イシハラ, トクヒロ
作成者所属山口大学医学部
内容記述(抄録等)Acute graft-versus-host reactions (GVHRs) to a male-specific (H-Y) antigen have been investigated using a weight assay, a bone marrow assay and a focal periportal proliferation test. Severe acute GVHRs have been marrow assay a focal periportal proliferation test. Severe acute GVHRs have been induced by the injection of female DA rat cells into male (Dax Lewis) F1 hybrid rats. Besides semiallogeneic donor RT1 antigens, host H-Y antigen was concerned strongly with leading to systemic acute GVHRs. Even though there were clinical variations, the acute GVHRs to H-Y antigen were occurred in F1 males, especially by the immunization with DA female spleen cells. When F1 hosts were splenectomized, only mild to moderate acute GVHRs were recognived by the injection of either female or male donor cells. The donor cells obtained from Lewis females that were premmunized with one rat died of typical acute graft-versus-host disease (GVHD). But in the other 3, chromic graft rejection was suggested to add to the GVHRs. Hemolytic anemia and ballooning change of hepatocytes were developed at around 41-63 days after immunization. Acute GVHRs to H-Y antigen led to remarkable erythroid suppression on bone marrow and focal myeloid proliferation in liver.
本文言語eng
著者キーワードAcute GVHR
H-Y antigen
F1 hybrid rat
Splenectomy
Erythropoiesis
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
36
3-4
開始ページ61
終了ページ67
発行日1989-12
著者版/出版社版出版社版
リポジトリIDA020036000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020036000302