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フルテキストURLA020048000103.pdf ( 3.4MB ) 公開日 2010-04-19
タイトルThe Effect of Hepatocyte Growth Factor (HGF) on Promotion of Endothelial Healing of Balloon-injured Carotid Artery
作成者Harada, Masakazu
Takenaka, Hiroaki
Zempo, Nobuya
Esato, Kensuke
Nagano, Tomokazu
Taiji, Mutsuo
Noguchi, Hiroshi
作成者ヨミハラダ, マサカズ
タケナカ, ヒロアキ
ゼンポ, ノブヤ
エサト, ケンスケ
ナガノ, トモカズ
タイジ, ムツオ
ノグチ, ヒロシ
作成者所属山口大学医学部
内容記述(抄録等)Purpose: This animal study was designed to examine the effect of hepatocyte grouth factor on suppression of intimal hyperplasia resulting from reendothelialization after balloon injury in the rat carotid artery. Methods: Fourteen Sprague-Dawely rats were subjected to balloon injury; treatment groups in which 0.1mg/body HGF (0.1mg HGF group; n=5) or 0.2mg/body HGF (0.2-mg HGF group; n=3) was infused in the same way. Rats were killed 14 days after surgery, and the carotid artery was harvested. Results: Intima/media (I/M) ratio was 0.98±0.15 in the control group, 0.73±0.17 in the 0.1-mg HGF group and 0.65±0.05 in the 0.2-mg HGF group. Reendothelialization extended 3.4±0.74 mm in the control group, 5.5±0.5 mm in the 0.1-mg HGF group and 5.6±2.1 mm in the 0.2-mg HGF group at the proximal site. These were no significant differences between groups in I/M ratio or reendothelialization. Conclusion: HGF is not effective on intimal healing in this model in terms of endothelial cell ingrowth and suppression of intimal thickening.
本文言語eng
著者キーワードhepatocyte growth factor (HDF)
balloon injury
endothelial healing
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
48
1-2
開始ページ13
終了ページ19
発行日2001-06
著者版/出版社版出版社版
リポジトリIDA020048000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020048000103