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フルテキストURLA020048000102.pdf ( 3.2MB ) 公開日 2010-04-19
タイトルNUCLEAR p53 OVEREXPRESSION IN PATHOLOGICAL T1BLADDER CANCER: A MARKER FOR TUMOR RECURRENCE AND TUMOR PROGRESSION
作成者Tsukamoto, Manabu
Oba, Kazuo
Yoshihiro, Satoru
Matsuyama, Hideyasu
Takahashi, Mutsuo
Naito, Katsusuke
作成者ヨミツカモト, マナブ
オオバ, カズオ
ヨシヒロ, サトル
マツヤマ, ヒデヤス
タカハシ, ムツオ
ナイトウ, カツスケ
作成者別表記松山, 豪泰
高橋, 睦夫
作成者所属山口大学医学部
内容記述(抄録等)In order to investigate the malignant potential of stage T1 bladdar tumors the status of p53 overexpression and mucosal change of grossly normal bladder mucosa, respectively, were studied regarding tumor recurrence and tumor progresion. A total of 30 cases with stage T1 bladder tumor were enrolled and selected site mucosal biopsies (SSMB) were taken of randomly selected 17 cases. All cases were treated by transurethral resection and followed for a median period of 39 months. Six of the 30 cases (20%) showed p53 overexpression. Five of the 17 (29%) had mucosal changes (carcinoma in situ;1, dysplasia;4). Out of 6 cases with p53 overexpression, 3 (50%) showed tumor progression, in contrast to only 2 (8%) of 24 cases without p53 overexpession (p<0.05, fisher's test). Statistically significant differences were found in recurrence-free and progression-free survival between patients whose tumor had p53 overexpression and those whose tumor did not (both p<0.01, Log Rank test). Signficant correlations were not found between mucosal change of grossly normal bladder mucosa and tumor recurrence, or progressin. These results suggest that p53 overexpression in the main tumor might be of useful prognostic marker for recurrence as well as tumor progression.
本文言語eng
著者キーワードp53 overexpression
bladder cancer
mucosal change
tumor recurrence
tumor progression
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
48
1-2
開始ページ7
終了ページ12
発行日2001-06
著者版/出版社版出版社版
リポジトリIDA020048000102
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020048000102