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タイトルラットにおける^<99m>Tc-フィチン酸の血液クリアランス並びに肝摂取率と肝障害との関係
タイトルヨミラット ニオケル^<99m> Tc フィチン サン ノ ケツエキ クリアランス ナラ ビニ カンセッシュリツ ト カンショウガイ トノ カンケイ
タイトル別表記Possible Relation between Blood Clearance and Hepatic Uptake of ^<99m>Tc-Phytake and Severity of Hepatic Injury in Rats
作成者柴田, 浩
久野, 友幸
作成者ヨミシバタ, ヒロシ
ヒサノ, トモユキ
作成者別表記Shibata, Hiroshi
Hisano, Tomoyuki
作成者所属山口大学農学部
内容記述(抄録等)The relation between the blood clearance and hepatic uptake of ^<99m>Tc-phytate (^<99m>Tc-P) and severity of hepatic injury was investigated by using the rats induced hepatic injury with carbon tetrachloride (CC1_4), D-galactosamine (GaIN), α-naphthy1-isothiocyanate (ANIT) or DL-ethionine (EthN). After the administration of CC1_4 GaIN or ANIT, serum GPT activity increased significantly with the increase of dose level, and the degree of this increase was in the order : GaIN > CC1_4 > ANIT. However, the mild increase in serum GPT activity was observed after EthN administration. The blood clearance rate of ^<99m>Tc-P and the hepatic uptake ratio of ^<99m>Tc-P decreased with the increase of dose level after CC4_4, GaIN or ANIT administration, but significant changes were not found after EthN administration. The degree of decrease in the blood clearance rate of ^<99m>Tc-P was in the order : GaIN ≒ CC1_4 > ANIT, and the degree of decrease in the hepatic uptake ratio of ^<99m>Tc-P was in the order : GaIN ≒ CC1_4 > ANIT. These results suggest that the disorder in the hepatocytes may be one of causes for inducing the decrease in the hepatic uptake ratio of ^<99m>Tc-P, and the consequence of this decrease may induce the decrease in the blood clearance of ^<99m>Tc-P.
本文言語jpn
主題農学
資料タイプtext
出版者山口大学農学部
出版者ヨミヤマグチ ダイガク ノウガクブ
NII資料タイプ紀要論文
ISSN0513-1715
NCIDAN00244250
学内刊行物(紀要等)山口大学農学部学術報告
掲載誌名山口大学農学部学術報告
掲載誌名別表記Bulletin of the Faculty of Agriculture, Yamaguchi University
37
開始ページ37
終了ページ48
発行日1989
著者版/出版社版その他
リポジトリIDD490037000003
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/D490037000003