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フルテキストURLA020049000303.pdf ( 224.0KB ) 公開日 2010-04-19
タイトルCyberknife radiosurgery / radiotherapy for brain metasis: prognostic factors for local control
作成者Jimi, Yasutaka
M. D.
作成者ヨミジミ, ヤスタカ
作成者所属山口大学医学部
内容記述(抄録等)Purpose: Homogrnrous irradiation and delivery of fractionated radiotherapy using the CyberKnife are useful treatments for brain metastases. Here we present our results of local tumor control after CyberKnife treatment. Materials and Methods: Local tumor control was evaluated for 107 lesions in 60 patients with radiological follow-up histories longer than 1 month (range 1.1 - 36.4 months, median 6.7 months). Also, tumor shrinkage time (TST) was assessed for 98 lesions by magnetic resonance imaging. The median and mean tumor volumes per patient were 2.8 and 6.1 cm3 (range 0.1-38.4 cm3), respectivery, at the time of the intial CyberKnife treatment. The mean marginal dose was 20.1 Gy (range 11.6-24.9 Gy, median 20.3 Gy). Forty-two cases (70%) involved a single lesion, and 18 (30%) involved multiple lesions, ranging in number from 2 to 7. Results: We found no permanent symptoms resulting from radiation necrosis during the follow-up periods after CyberKnife treatment. Actuarial local control rates were 88% and 63% at 6 months, with 1year, respectively. The median time to local failure was 5.8 months., with a range of 3.0-21.9 months. TST analysis showed that large tumor volume and low marginal dose were still associated with poor tumor control. CyberKnife treatment was unable to control the tumor in 18 of 106 tumors. However, none of the patients who underwent additional radiosurgery or other surgical procedure died of brain metastasis. Conclusion: CyberKnife treatment is a useful modality which can be the first choice for treatment of brain metastasis.
本文言語eng
著者キーワードCyberKnife
brain metastasis
local tumor control
tumor shrinkage time
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
49
3-4
開始ページ55
終了ページ62
発行日2002-12
著者版/出版社版出版社版
リポジトリIDA020049000303
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020049000303