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フルテキストURLA020014000104.pdf ( 768.0KB ) 公開日 2010-04-16
タイトルThe Effect of Zinc on the Central Nervous System : Increase in Brain Excitability and Initiation of Seizures Following Systemic and Intracerebral Administration of Zinc
作成者Fuchimoto, Takeshi
Watanabe, Masanori
Fujii, Masataka
Takashima, Masanari
Hiraoka, Hiroshi
作成者ヨミフチモト, タケシ
ワタナベ, マサノリ
フジイ, マサタカ
タカシマ, マサナリ
ヒラオカ, ヒロシ
作成者所属山口大学医学部
内容記述(抄録等)1. The effect of zinc on the central nervous system was investigated in conscious mice using electroshock seizure threshold tests and whole animal behavioral studies. 2. Single or successive subcutaneous injection of zinc markedly decreased EST. This EST-lowering effect was abolished in adrenalectomized mice, indicating that the decrease in EST following systemic injection of zinc is produced by way of the adrenal gland. 3. Intracerebral injection of lower concentrations of zinc produced a marked decrease in EST in intact and adrenalectomized mice. 4. Intracerebral injection of higher concentrations of zinc produced the following behavioral changes. A) A concentration of 4 mM or more of zinc (2.6 μg or more Zn per 0.01 ml) produced running or hopping movements, which were followed by convulsive seizures with a latency of about 50 sec. The seizure pattern was almost always tonic flexor-tonic extensor type. B) Such seizure responses seemed to be rather specific for zinc, since copper produced a different type of seizure responses and several heavy metals had little effect on behavior. C) Diphenylhydantoin, phenobarbital and acetazolamide protected the tonic extensor seizures but failed to eliminate the running or hopping movements preceding the seizures. Calcium completely protected the behavioral responses to zinc, while the protective effect of magnesium was insufficient. 5. Possible mechanisms concerning the direct effect of zinc on the brain are discussed.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
14
1
開始ページ67
終了ページ78
発行日1967-03
著者版/出版社版出版社版
リポジトリIDA020014000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020014000104