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フルテキストURLA020008000305.pdf ( 825.0KB ) 公開日 2010-04-16
タイトルStudies on an Antidiuretic Substance in the Bile -Report Ⅱ. Physiological fate of the biliary antidiuretic substabce-
作成者Mizuta, Minoru
Kiyonaga, Denji
Yano, Fujitaka
Sasaki, Nobuhiro
作成者ヨミミズタ, ミノル
キヨナガ, デンジ
ヤノ, フジタカ
ササキ, ノブヒロ
作成者所属山口大学医学部
内容記述(抄録等)1) Human B-bile was distinctly greater in antidiuretic activity than human C-bile. The b-bile was diluted with water to the extent that its bilirubin concentration equaled that of C-bile, and its antidiuretic activity was assayed in comparison with the C-bile. The diluted B-bile was found to be less potent in activity than the C-able. It was therfore thought that a part of antidiuretic substance might be reasorbed from the wall of the gall bladder. 2) Direct infusion of the biliary ADS into an isolated gall bladder of a rabbit, in which continuos diuresis had been induced, immediately lead to a cessation of urine outflow. This also indicates that the biliary ADS is reabsorbed from the gall bladder. 3) No antiduretic activity was demonstrated in human gastric juice. 4) The biliary ADS was stable in human gastric juice or C-bile. 5) The biliary ADS was resistant to pepsin treatment but was inactivated by trypsin or intestinal mucosa extract. 6) Introduction of the biliary ADS into the rat stomach or into the rabbit intestine resulted in no depression of diuresis. 7) The bilary ADS was inactivated by perfusion through an isolated rabbit liver and by rat liver extract. 8) The biliary ADS probably has the same properties as Pitressin except that the latter is stable during trypsin treatment. 9) It has been concluded that the biliary ADS is reabsorbed from the gall bladder and inactivated in the intestine. Even though it is not completely in activated in the intestine, there is no absorption from the intestinal wall. While circulating in the blood stream, it is inactivated by the liver.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
8
3
開始ページ231
終了ページ245
発行日1961-09
著者版/出版社版出版社版
リポジトリIDA020008000305
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020008000305