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フルテキストURLA050055000302.pdf ( 630.7KB ) 公開日 2010-04-19
タイトルImmunoglobulin G1 allotypes in intravenous immunoglobulin non-responders of kawasaki disease patients
作成者Takegawa, Tsuyoshi
Matsubara, Tomoyo
Okuda, Masayuki
Kaneko, Miho
Ichiyama, Takashi
Furukawa, Susumu
作成者ヨミタケガワ, ツヨシ
マツバラ, トモヨ
オクダ, マサユキ
カネコ, ミホ
イチヤマ, タカシ
フルカワ, ススム
作成者別表記竹川, 剛史
奥田, 昌之
市山, 高志
古川, 漸
作成者所属山口大学大学院医学系研究科(医学)
山口大学大学院理工学研究科(医学)
内容記述(抄録等)The standard therapy for Kawasaki disease (KD) consists of intravenous immunoglobulin (IVIG) treatment. However, at least 10% of KD patients fail to exhibit defervescence with initial IVIG therapy, and they are defined as IVIG non-responders. We investigated the prevalence of certain GM allotypes in IVIG responder and non-responder KD patients. Sera obtained from 83 KD patients and 34 controls were tested for G1M(1), G1M(2), G1M(3), and G1M(17) by using the standard agglutinationinhibition method. All the patients were treated with IVIG, and 14 patients were identified as IVIG non-responders. All samples tested were positive for the G1M(1) and G1M(17). With regard to G1M(2), 8 of 14 (57.1%) IVIG non-responders, 19 of 69 (27.5%) IVIG responders, and 7 of 34 (20.6%) controls tested were positive for this allotype. G1M(3) was detected in 9 (13%) responders, 3 (21.4%) non-responders. A significant difference in the G1M(2) distribution was noted between the non-responders and controls (p = 0.019). The G1M(2) was found to be significantly associated with the IVIG non-responders after adjustments for age, sex, and each allotype (odds ratio, 3.59; 95%confidence interval, 1.03-12.46; p = 0.040). IVIG treatment was 8.97 times more likely to fail in patients with the G1M phenotype (1,2,3,17) (95% confidence interval 1.41-57.21, p = 0.020). In conclusions, the G1M(2) allotype may be associated with KD patients who were IVIG non-responders.
本文言語eng
著者キーワードKawasaki disease
intravenous immunoglobulin
G1M allotype
IVIG non-responder
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University School of Medicine
NII資料タイプ紀要論文
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
55
3-4
開始ページ27
終了ページ33
発行日2008
関連情報URL(IsPartOf)http://ds.cc.yamaguchi-u.ac.jp/~bulletin/index.html
著者版/出版社版出版社版
リポジトリIDA050055000302
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A050055000302