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フルテキストURLA020028000109.pdf ( 373.4KB ) 公開日 2010-04-19
タイトルThe Host's Cellular Immune Status and Therapy for Liver Cancer
作成者Nishioka, Mikio
Kan, Taizo
Kan, Mami
Kodama, Takahiro
Nawata, Junsuke
Harada, Toshinori
Nishimura, Hideo
Takemoto, Tadayoshi
作成者ヨミミシオカ, ミキオ
カン, タイゾウ
カン, マミ
コダマ, タカヒロ
ナワタ, ジュンスケ
ハラダ, トシノリ
ニシムラ, ヒデオ
タケモト, タダヨシ
作成者所属山口大学医学部
内容記述(抄録等)Lipopolysaccharides (LPS) from Salmonella typhosa was injected into the peritoneum of ICR mice. Light and electron microscopic changes of neutrophils in both the systemic circulation and in the marginal zone of the spleen were studied, both without (Oh) and 0.5, 1, 2, 4, 6, 8, 12, 24, 36 and 48h after the LPS treatment. Sequestration of the circulating neutrophils into the marginal zone of the spleen was observed after the LPS treatment. The neutrophils both in the circulation and in the marginal zone of the spleen were damaged by the LPS treatment, as evidenced by 1) toxic cytoplasmic granules, 2) degranulation and vacuolation, 3) dilatation of the rough- and smooth-surfaced endoplasmic reticulums and 4) dilatation of the nuclear envelope. The damage was most marked some or all of the above mentioned signs of damage, while 100% of the neutrophils in the marginal zone of the spleen did so. The degree of damage was more marked in the neutrophils in the marginal zone than in those of the circulation. It was concluded from these findings that the splenic marginal zone actively traps the neutrophils damaged by the bacterial toxin, rather than being invaded by, undamaged neutrophils from the circulation. The trapping most likely is done by the reticulum cell meshwork in the marginal zone, helped in part by phagocytes.
本文言語eng
著者キーワードprimary carcinoma
cellular immune status
chemotherapy
skin test
immune parameter
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
28
1-2
開始ページ63
終了ページ68
発行日1981-06
著者版/出版社版出版社版
リポジトリIDA020028000109
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020028000109