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フルテキストURLA020036000105.pdf ( 599.6KB ) 公開日 2010-04-19
タイトルDifferential Effects of Des-Tyrosine-γ-Endorphin on Clinical Symptoms and EEGs in Schizophrenia
作成者Mizuki, Yasushi
Suetsugi, Masatomo
Nakamura, Kai
Kajimura, Naofumi
Yamada, Michio
作成者ヨミミズキ, ヤスシ
スエツギ, マサトモ
ナカムラ, カイ
カジムラ, ナオフミ
ヤマダ, ミチオ
作成者所属山口大学医学部
内容記述(抄録等)The clinical prospects of des-tyrosine-γ-endorphin (DTγE) in schizophrenia ware examined. Six male inpatients with schizophrenia ware administered fixed doses of neuroleptics during this study. The EEG recording and BPRS scoring ware done before DTγE administration. One mg/day of DTγE and of placebo were given intramuscularly in a doubleblind, crossover design for 2 consecutive weeks, followed by 1 week of no drug treatment. The EEG recording and BPRS scoring ware carried out once weekly. There were no significant differences in either the total BPRS scores or the scores of individual items between DTγE and placebo. With DTγE treatment, the power values of frontal EEGs increased slightly in the α activity during the study. The EEG values of the occipital area decreased in terms of slow wave and α activities during the study. The power of the left temporal area decreased in terms of slow wave activity in the first week but decreased in term of fast β activity in the second and third weeks. The power of the right temporal area decreased in terms of whole bands in the first week but decreased in β activity in the second and third weeks. These results suggest that treatment with DTγE might not improve the overt symptoms of schizophrenics but might affect their EEGs in a delayed manner.
本文言語eng
著者キーワードNeuropeptide
Des-tyrosine-endorphin
Schizophrenia
Clinical symptoms
Pharmaco-EEG
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
36
1-2
開始ページ29
終了ページ35
発行日1989-06
著者版/出版社版出版社版
リポジトリIDA020036000105
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020036000105