| フルテキストURL | A020036000105.pdf ( 599.6KB ) 公開日 2010-04-19
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| タイトル | Differential Effects of Des-Tyrosine-γ-Endorphin on Clinical Symptoms and EEGs in Schizophrenia |
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| 作成者 | Mizuki, Yasushi
Suetsugi, Masatomo
Nakamura, Kai
Kajimura, Naofumi
Yamada, Michio
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| 作成者ヨミ | ミズキ, ヤスシ
スエツギ, マサトモ
ナカムラ, カイ
カジムラ, ナオフミ
ヤマダ, ミチオ
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| 作成者所属 | 山口大学医学部
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| 内容記述（抄録等） | The clinical prospects of des-tyrosine-γ-endorphin (DTγE) in schizophrenia ware examined. Six male inpatients with schizophrenia ware administered fixed doses of neuroleptics during this study. The EEG recording and BPRS scoring ware done before DTγE administration. One mg/day of DTγE and of placebo were given intramuscularly in a doubleblind, crossover design for 2 consecutive weeks, followed by 1 week of no drug treatment. The EEG recording and BPRS scoring ware carried out once weekly. There were no significant differences in either the total BPRS scores or the scores of individual items between DTγE and placebo. With DTγE treatment, the power values of frontal EEGs increased slightly in the α activity during the study. The EEG values of the occipital area decreased in terms of slow wave and α activities during the study. The power of the left temporal area decreased in terms of slow wave activity in the first week but decreased in term of fast β activity in the second and third weeks. The power of the right temporal area decreased in terms of whole bands in the first week but decreased in β activity in the second and third weeks. These results suggest that treatment with DTγE might not improve the overt symptoms of schizophrenics but might affect their EEGs in a delayed manner.
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| 本文言語 | eng
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| 著者キーワード | Neuropeptide
Des-tyrosine-endorphin
Schizophrenia
Clinical symptoms
Pharmaco-EEG
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| 主題 | 医学
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| 資料タイプ | text |
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| ファイル形式 | application/pdf |
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| 出版者 | Yamaguchi University Graduate School of Medicine
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| NII資料タイプ | 紀要論文 |
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| ISSN | 0513-1812
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| NCID | AA00594272
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| 学内刊行物(紀要等) | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名 | The bulletin of the Yamaguchi Medical School |
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| 掲載誌名別表記 | 山口医科大学紀要 |
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| 巻 | 36 |
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| 号 | 1-2 |
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| 開始ページ | 29 |
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| 終了ページ | 35 |
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| 発行日 | 1989-06 |
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| 著者版/出版社版 | 出版社版 |
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| リポジトリID | A020036000105 |
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| 地域区分 | 山口大学
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| URI | http://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020036000105 |
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