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フルテキストURLA020036000104.pdf ( 582.9KB ) 公開日 2010-04-19
タイトルComparative Study with CHOP-Pepleo and COP-Pepleo Combunation Chemotherapy for Non-Hodgkin's Lymphoma
作成者Tanaka, Masahisa
Azuno, Yoichi
Yoshizaki, Yoshiki
Hatao, Katsuhiro
Fujii, Yasuhiko
Okubo, Masashi
Inoue, Yasushi
Matsutani, Akira
Yaga, Ken
Fujii, Shinya
Ishida, Yoji
Kaku, Kohei
Matsumura, Shigeichi
Kaneko, Toshio
Shinohara, Kenji
Hiroshige, Yukio
Matsumoto, Noboru
作成者ヨミタナカ, マサヒサ
アズノ, ヨウイチ
ヨシザキ, ヨシキ
ハタオ, カツヒロ
フジイ, ヤスヒコ
オオクボ, マサシ
イノウエ, ヤスシ
マツタニ, アキラ
ヤガ, ケン
フジイ, シンヤ
イシダ, ヨウジ
カク, コウヘイ
マツムラ, シゲイチ
カネコ, トシオ
シノハラ, ケンジ
ヒロシゲ, ユキオ
マツモト, ノボル
作成者所属山口大学医学部
内容記述(抄録等)Combination chemotherapy with CHOP-Pepleo regimen (cyclophosphamide, adriamycin, vincristine, prednisolone, and pepleomycin), or COP-Pepleo refimen (cyclophosphamide, vincristine, prednisolone, and pepleomycin), was used as a remission induction therapy for patients with mostly advanced non-Hodgkin's lymphomas. Among 23 patients treated with CHOP-Pepleo or CHOP without Pepleo (5 patients), 57% achieved complete remission with 78% overall response (complete remission plus partisl remission). Among 12 patients treated with COP-Pepleo, 50% achieved complete remissions with 83% overall response. No significant difference was odserved in response rates between two groups. Median follow-up durations ware 14 months for CHOP-People and 16 months for COP-Pepleo and 4 patients (67%) treated with COP-Pepleo relapsed within 20 months after achieving complete remission. Relapse-free survival rates at 4 years ware 54% for CHOP-Pepleo and 34% for COP-Pepleo. Each survival curve in the patients treated with CHOP-Pepleo or COP-Pepleo showed a plateau after 24 months. Though the addition of adriamycin did not improve complete remission rate significantly as a whole, the complete remission rate in stage Ⅳ , overall survival and relapse-free survival ware favorably inproved by the addition of adriamycin. Further study will be needed to assess the effect of adriamycin on response and survival in patients eith non-Hodgkin's lymphomas.
本文言語eng
著者キーワードNon-Hodgkin's Lymphoma
Chemotherapy
CHOP-Pepleo
COP-Pepleo
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
36
1-2
開始ページ21
終了ページ27
発行日1989-06
著者版/出版社版出版社版
リポジトリIDA020036000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020036000104