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フルテキストURLフルテキストリンクなし
タイトルEffects on liver functions of gastric variceal therapy by endoscopic ligation using a detachable snare and sclerotherapy with O-ring ligation
作成者Segawa, Makoto
Sakaida, Isao
Takeo, Yoshifumi
Harada, Toshiya
Yoshida, Tomoharu
Okita, Kiwamu
作成者ヨミセガワ, マコト
サカイダ, イサオ
タケオ, ヨシフミ
ハラダ, トシヤ
ヨシダ, トモハル
オキタ, キワム
作成者別表記瀬川, 誠
坂井田, 功
作成者所属山口大学医学部附属病院
山口大学大学院医学系研究科(医学)
内容記述(抄録等)Although various effects of therapy for gastric varices, a complication of portal hypertension, on portal hemodynamics have been suggested, the effects of the therapy on liver functions have not yet been clarified. The aim of this study was to examine the effects of endoscopic gastric variceal therapy on liver functions in patients with hepatic cirrhosis. The subjects were 18 hepatic cirrhosis patients with the complication of gastric varices, who could be monitored for a long term (at least 1-year after therapy). They consisted of patients receiving prophylactic treatments after being confirmed to have a risk of rupture of gastric varices (16 prophylactic cases) and those with a history of bleeding and receiving palliative treatments to prevent rebleeding (two palliative cases). To evaluate liver functions, blood tests before the therapy, just after the therapy and at 1, 3, 6 and 12 months after the therapy were retrospectively examined and the levels of albumin, total bilirubin (T.Bil), ALT, choline esterase (ChE), platelets and the Child-Pugh classification were assessed. The albumin levels tended to increase after the therapy, and the level at 6 months after the therapy was significantly higher than the pre-treatment value (P=0.0311). At 1 year after the therapy, the level was higher than the pre-treatment value, but there was no significant difference. The ChE level tended to decrease just after the therapy, but it tended to be increased at 3 and 6 months after the therapy. Although significant improvement was not seen in T.Bil, ALT, platelet levels or the Child-Pugh classification after the therapy, none of these worsened. Endoscopic gastric variceal ligation therapy significantly improved liver functions, or at least albumin synthesis.
本文言語eng
著者キーワードEndoscopic variceal ligation
Gastric varices
Hepatic function
資料タイプtext
出版者Elsevier
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN1386-6346
NCIDAA11140867
掲載誌名Hepatology research : the official journal of the Japan Society of Hepatology
24
4
開始ページ420
終了ページ428
発行日2002
DOIinfo:doi/10.1016/S1386-6346(02)00134-1
関連情報URL(IsPartOf)http://www.sciencedirect.com/science/journal/13866346
著者版/出版社版その他
リポジトリID2008010381
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2008010381