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フルテキストURLA020020000104.pdf ( 574.4KB ) 公開日 2010-04-16
タイトルRadioprotective Action of SH Compounds Ⅱ. Effect of Glutathione on the Mitotic Delay Induced by X-Ray.
作成者Kawasaki, Shoji
作成者ヨミカワサキ, ショウジ
作成者所属山口大学医学部
内容記述(抄録等)The radioprotective action of GSH was studied at the cytological level using the mitotic index of Ehrlich ascites tumor cells. 1. In the irradiation with 100 or 200 rads, the rate of recovery of mitotic index in the treated with 30 mg GSH was similar to that in the control group. But 12 hours after the irradiation and on, the mitotic index increased more than the value of the control. 2. With 400 or 600 rads, the recovery of the mitotic indez was accelerated by the pretreatment with 30 mg GSH. 3. Irradiation with 400 rads 30 minutes, 3 hours and 6 hours after administration of 30 mg GSH resulted in the fastest recovery of mitotic index in the group where GSH was given 30 minutes before irradiation, followed by the group given GSH 6 hours previously. 4. Of the administration of GSH (30 mg) at 30 minutes, 3 hours, 6 hours and 9 hours aftei irradiation with with 400 rads the one that gave the most intense inhibition that 3 hours after irradiation. A slight inhibition was senn when administered at 9 hours after irradiation. 5. Treatment with GSH alone induced a slight decrease in the mitotic index and later a marked increase at 9 to 12 hours. On the basis of these date, the mechanisms of the radioprotective action of GSH were discuseed.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
20
1-2
開始ページ33
終了ページ44
発行日1973-06
著者版/出版社版出版社版
リポジトリIDA020020000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020020000104