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フルテキストURLA020020000103.pdf ( 623.1KB ) 公開日 2010-04-16
タイトルRadioprotective Action of SH Compounds Ⅰ. Stusies Based on Survival Rate Curve
作成者Kawasaki, Shoji
作成者ヨミカワサキ, ショウジ
作成者所属山口大学医学部
内容記述(抄録等)The radioprotective effect of SH compounds (GSH, MEA, AET, MPG and DTT) was studied by using of 30-day survival rate in mice and obtained the following results. 1. DRF (dose reduction factor) of GSH (30 mg), MEA (4 mg), AET (3 mg) and AET 86 mg) was 1.09, 1.54, 1.29 and 1.31 at LD50 respectively. 2. The dose-effect curve og GSH and MEA had a slope approximately similar to that of the contral group. The slope was less steep for AET. 3. n administering MEA at intervals of 60 minutes before irradiation and 30 minutes after irradiation, the best effect was obtained with administration 30 minutes before irradiation. 4. When the GSH administration was shifted to repeated irradiation, positive effect was obtained in the administration at 3 hours or 30 minutes before irradiation and a poorer effect in the administration at 6 hours before irradiation. Administration after irradiation gave no effect. 5. When the GSH administration was shifted to repeated irradiation, 30 mg of GSH gave the best effect. 6. Protective effect other compounds in the dose of 3 mg, 6 mg AET or 3 mg MEA, was also observed for repeated irradiation. AET (6 mg) had the best protective effect of all the SH compounds tested. On the basis of these experimental results, the author explained the radioprotection of SH compounds.
本文言語eng
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
20
1-2
開始ページ17
終了ページ31
発行日1973-06
著者版/出版社版出版社版
リポジトリIDA020020000103
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020020000103