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フルテキストURL2008010283.pdf ( 563.4KB ) 公開日 2010-04-16
タイトルProphylactic activity of ivermectin against Dirofilaria immitis infection in dogs : Establishment of effective dose and administration schedule
作成者Ohishi, Isamu
Katae, Hiromi
Hayasaki, Mineo
Nakagaki, Kazuhide
Tada, Yusuke
作成者ヨミオオイシ, イサム
カタエ, ヒロミ
ハヤサキ, ミネオ
ナカガキ, カズヒデ
タダ, ユウスケ
作成者別表記早崎, 峯夫
作成者所属山口大学農学部
内容記述(抄録等)To establish a recommended dose and prophylactic program of ivermectin for preventing D. immitis infection, antilarval activity of ivermectin at 3 or 6μg/kg against one day, 30 and 60 days old larvae was evaluated. The worms were recovered from all dogs given ivermectin at 3μg/kg one day after inoculation with an average infection ratio of 21.9%. One male worm was recovered from one of 6 dogs given ivermectin at 3μg/kg 30 days after inoculation with an extremely low average infection ratio of 0.1%. Out of 6 dogs given ivermectin at 3μg/kg 60 days after inoculation, 3 animals yielded worms with a low infection ratio of 4.0%. The results suggest that ivermectin at 3μg/kg demonstrates incomplete antilarval activity against D. immitis larvae of one day, 30 and 60 days old and is not suitable to monthly or bimonthly interval mdication for preventing D. immitis infection. Small numbers of the worms were recovered from 5 of 6 dogs given ivermectin at 6μg/kg one day after inoculation with an average infection ratio of 5.7%. No worms were recovered from all dogs given ivermectin at 6μg/kg 30 and 60 days after inoculation. The results show that a single oral dose of ivermectin at 6μg/kg, though the dose demonstrates incomplete antilarval activity against one day old larvae, would be a recommended dose which can completely kill the larvae which are naturally infected at any time when the dose is given once a month at one month interval during the period from one month after the first infection to one month after the last infection of D. immitis.
本文言語eng
著者キーワードDirofilaria immitis
dog
ivermectin
larvicidal activity
資料タイプtext
ファイル形式application/pdf
出版者日本獣医学会
出版者ヨミニホン ジュウイ ガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0021-5295
NCIDAA10521639
掲載誌名Japanese journal of veterinary science
49
3
開始ページ439
終了ページ445
発行日1987
関連情報URL(IsPartOf)http://www.jstage.jst.go.jp/browse/jvms/-char/ja
Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis
著者版/出版社版出版社版
リポジトリID2008010283
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2008010283