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フルテキストURL2008010282.pdf ( 515.6KB ) 公開日 2010-04-16
タイトルInfluence of immune treatments against Dirofilaria immitis infection in dogs
作成者Hayasaki, Mineo
Ohishi, Isamu
作成者ヨミハヤサキ, ミネオ
オオイシ, イサム
作成者別表記早崎, 峯夫
作成者所属山口大学農学部
内容記述(抄録等)Mongrel dogs were inoculated with two kinds of antigenic substances. The first was a phosphate buffered saline extract of whole Dirofilaria immitis mixed with aluminum hydroxide gel (group 1), and the second was an orally administered live Metastrongylus apri infective larvae (L_3) (group 2). Both groups were then infected with D. immitis L_3. Indirect hemagglutination (IHA) tests showed that the antibody was produced by these inoculations before the infection was introduced, even in dogs inoculated with M. apri. This suggests a cross-reactivity between D. immitis and M. apri. The initial passive cutaneous anaphylaxis (PCA) antibody production was markedly delayed by about 70 days in group 2 compared with the production in the infected control dogs (group 3). The appearance of microfilaremia was also delayed by about one month in group 2 compared with that in the above control group. All dogs were sacrificed after the termination of the observation and worms recovered from the right ventricle and pulmonary arteries were counted and measured. The results indicated that immunization resulting from the homologous worm-somatic antigen might accelerate the growth of the infected larvae, whereas immunization resulting from the heterologous worm antigen, but cross-reactive to D. immitis, might disadvantageously affect the growth.
本文言語eng
著者キーワードDirofilaria immitis
immune treatment
Metastrongylus apri
資料タイプtext
ファイル形式application/pdf
出版者日本獣医学会
出版者ヨミニホン ジュウイ ガッカイ
NII資料タイプ学術雑誌論文
査読の有無査読あり
ISSN0021-5295
NCIDAA10521639
掲載誌名Japanese journal of veterinary science
51
3
開始ページ540
終了ページ546
発行日1989
関連情報URL(IsPartOf)http://www.jstage.jst.go.jp/browse/jvms/-char/ja
Dirofilaria immitis infection and dirofilariosis : an animal model of human filariosis
著者版/出版社版出版社版
リポジトリID2008010282
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/2008010282