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フルテキストURLA020037000104.pdf ( 2.0MB ) 公開日 2010-04-19
タイトルThe Measurement of Brainstem Blood Flow in the Experimental Recirculation Model of Brainstem Ischemia in the Rat
作成者Shiroyama, Yujiro
Nagamitsu, Tsutomu
Yamashita, Tetsuo
Abiko, Seisho
Ito, Haruhide
作成者ヨミシロヤマ, ユウジロウ
ナガミツ, ツトム
ヤマシタ, テツオ
アビコ, セイショウ
イトウ, ハルヒデ
作成者所属山口大学医学部
内容記述(抄録等)This report describes a surgical approach and measurement of brainstem blood flow (BBF) used in experimental ischemic model of the brainstem. The vertebral artery of Wistar rat was exposed and prepared embolic thread was inserted into the vertebral artery. The lesions of the baselar artery occuleded animals were restricted to the brainstem which, in the rat, is normally supplied by the vertebrobasilar artery. Using the hydrogen clearance techniques, blood flow of the brainstem was measured in 21 rats. The mean value of mean blood pressure (MBP) was 96.2±6.2 mmHg before ischemia. It dropped to 62.0±12.4 mmHg after transient hypertension. The preischemic BBF was 35.5±2.4 ml/100g/min. This was followed by a gradual increase to hyperperfusion after recirculation. After 1 hour of recirculation, BBF rose to a level above 78.9±5.9 ml/100g/min. These findings suggest that this model may be useful in the evaluation of pathophysiogical changes in brainstem ischemia.
本文言語eng
著者キーワードBrainstem
Ischemia
Recirculation
Hyperperfusion
Vasomotor center
主題医学
資料タイプtext
ファイル形式application/pdf
出版者Yamaguchi University Graduate School of Medicine
NII資料タイプ紀要論文
ISSN0513-1812
NCIDAA00594272
学内刊行物(紀要等)The bulletin of the Yamaguchi Medical School
掲載誌名The bulletin of the Yamaguchi Medical School
掲載誌名別表記山口医科大学紀要
37
1-2
開始ページ25
終了ページ30
発行日1990-06
著者版/出版社版出版社版
リポジトリIDA020037000104
地域区分山口大学
URIhttp://www.lib.yamaguchi-u.ac.jp/yunoca/handle/A020037000104